AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation
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منابع مشابه
Aberrant Lymphatic Endothelial Progenitors in Lymphatic Malformation Development
Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease on affected individuals. LM pathobiology is poorly understood, hindering the development of effective treatments. In the present studies, immunostaining of LM tissues revealed that endothelial cells lining aberrant lymphatic vessels and ...
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INTRODUCTION Mesenteric lymphatic malformations are rare, benign tumors that are most commonly found in children. The presentation of these tumors is variable and may either be innocuous or life threatening. It has been suggested that mesenteric lymphatic malformations are congenital; however, there is evidence that their growth may be stimulated by local trauma. CASE PRESENTATION We describe...
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OBJECTIVE To determine whether an immunologic abnormality exists in patients with lymphatic malformation (LM). DESIGN Retrospective case series. SETTING Tertiary care pediatric hospital. PATIENTS Twenty-one consecutive patients (11 male and 10 female) undergoing LM treatment. INTERVENTIONS Clinical data (ie, age, clinical LM stage, radiographic appearance, and histologic findings) were ...
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Cystic hygroma or macrocystic lymphatic malformation is a well-known entity and its diagnosis and management is also well described in literature. Rarely its size and location may pose management challenges.[1-3] We managed a case of humongous macrocystic lymphatic malformation of axilla and chest wall in a newborn. At 25 weeks of gestation, a 16cm mass was reported by antenatal ultrasound arou...
متن کاملFine filaments in lymphatic endothelial cells
Several and various types of cells contain fine cytoplasmic filaments closely resembling the myofilaments of muscle cells (2, 18, 23, 24). In many of these cells and especially when cultured, it has been demonstrated that some of these filaments react with heavy meromyosin (HMM) in the same way as do the actin filaments of muscle cells (3, 6 7). This suggests that these filaments may be actinoi...
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ژورنال
عنوان ژورنال: Angiogenesis
سال: 2014
ISSN: 0969-6970,1573-7209
DOI: 10.1007/s10456-014-9453-2